(NSO-01) Supporting the Shift: Inpatient Review of BCMA CAR-T Therapy in Multiple Myeloma Reveals Early Safety and Feasibility for a Nurse Lead Outpatient Model of Care
Imaging, QoL and Patient-Reported Outcome and Supportive Care
11:25 - 11:35 East Coast USA Time
(NSO-06) Identifying Gaps and Opportunities in Multiple Myeloma Care: Results from the “Opinions in MM Approaches and Challenges” Interactive Workshop Series
(OA-13) Post-Induction Outcomes and Updated Minimal Residual Disease Analysis from GMMG-HD10/DSMM-XX (MajesTEC-5): A Study of Teclistamab-Based Induction Regimens in Newly Diagnosed Multiple Myeloma (NDMM)
Location: Room 701
Abstract Presenter: Marc S. Raab, MD PhD (he/him/his) – Dept. of Medicine V Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany
Cellular and T cell engager Immunotherapy
11:10 - 11:20 East Coast USA Time
(OA-14) Cevostamab Plus Pomalidomide (Pom) and Dexamethasone (dex) in Relapsed/Refractory Multiple Myeloma (RRMM): Phase I Dose-Expansion Results from the CAMMA 1 Study
(OA-07) Elranatamab in Combination With Daratumumab and Lenalidomide (EDR) in Patients With Newly Diagnosed Multiple Myeloma (NDMM) Not Eligible for Transplant: Initial Results from MagnetisMM-6 Part 1
Location: Room 701
Abstract Presenter: Suzanne Trudel, MD – Princess Margaret Cancer Centre, Toronto, ON, Canada
Cellular and T cell engager Immunotherapy
11:30 - 11:40 East Coast USA Time
(OA-02) Sustained Remission After Limited-Duration of Bispecific Antibody Therapy in Patients with Relapsed/Refractory Multiple Myeloma
Location: Room 701
Abstract Presenter: Meera Mohan, MD – Medical College of Wisconsin
Cellular and T cell engager Immunotherapy
11:40 - 11:50 East Coast USA Time
(OA-35) TRIgnite- 1Study, Phase 1, First-in-Human Study of ISB 2001: A BCMAxCD38xCD3-Targeting Trispecific Antibody for Patients with Relapsed/Refractory Multiple Myeloma (RRMM)—Dose Escalation (DE) Results
(OA-29) In Situ Visualisation of BCMA Bispecific Antibody and the Myeloma Immune Microenvironment
Location: Room 718
Abstract Presenter: Jeremy Er, Bmed Sci, MBBS, FRACP, FRCPA – Hawkins laboratory, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
Clinical haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia
Myeloma Genomics and Microenvironment and immune profiling
11:10 - 11:20 East Coast USA Time
(OA-31) A Comprehensive Map of Genomic Drivers of Resistance to Anti-BCMA Immunotherapies in Multiple Myeloma
Myeloma Genomics and Microenvironment and immune profiling
11:20 - 11:30 East Coast USA Time
(OA-10) MZB1-Directed HLA-Dependent CAR T Cells for Targeting B-Cell Malignancies
Location: Room 718
Abstract Presenter: Elena Maroto Martin, PhD (she/her/hers) – Jerome Lipper Multiple Myeloma Disease Center, Dana-Farber Cancer Institute, Harvard Medical School
Cellular and T cell engager Immunotherapy
11:30 - 11:40 East Coast USA Time
(OA-15) S100A8/A9 Promotes T Cell Exhaustion and Impairs Response to Bispecific Therapy in Multiple Myeloma
Faculty: Efstathios Kastritis, MD, PhD (he/him/his) – Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
(PA-307) Iberdomide (Iber) Treatment (Tx) Enhances Manufactured Chimeric Antigen Receptor (Car) T Cell Expansion And Functionality And Is Immunostimulatory In Patients Post-Car T Cell Therapy
Myeloma Genomics and Microenvironment and immune profiling
12:38 - 12:44 East Coast USA Time
(PA-180) Revealing Clonal Evolution and Assessing Immune Reconstitution in Multiple Myeloma Using Next-Generation Sequencing-Based Minimal Residual Disease (NGS-MRD) Analysis
Location: Room 714A
Abstract Presenter: Yuntong Liu, liuyuntong@ihcam.ac.cn – Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
MRD and Biomarkers
12:44 - 12:50 East Coast USA Time
(PA-529) Risk of Infections after Bispecific Antibodies Targeting Anti-B-cell Maturation Antigen (BCMA) in Multiple Myeloma-intravenous Immunoglobulin (IVIG) Significantly Lowers the Risk of Infection
Chair: Thierry Facon, MD – University of Lille, CHU Lille, Service des Maladies du Sang, Lille, France
Co-Chair: Francesca Gay, MD (she/her/hers) – Division of Hematology 1, Clinical trial unit AOU città della salute e della scienza, University of Torino
14:30 - 15:50 East Coast USA Time
Core Session 2: Risk Adaptation Management
Location: Hall FG
Chair: Thierry Facon, MD – University of Lille, CHU Lille, Service des Maladies du Sang, Lille, France
Co-Chair: Francesca Gay, MD (she/her/hers) – Division of Hematology 1, Clinical trial unit AOU città della salute e della scienza, University of Torino
14:30 - 14:40 East Coast USA Time
Risk assessment of newly diagnosed MM: genetic and biological risk factors
(OA-17) MRI Response According to MY-RADS Correlates with MRD Negativity After Induction in Newly Diagnosed Multiple Myeloma: Results from the GMMG-HD7 Trial
Location: Room 701
Abstract Presenter: Marina Hajiyianni, MD – Heidelberg Myeloma Center, Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany
Imaging, QoL and Patient-Reported Outcome and Supportive Care
16:40 - 16:50 East Coast USA Time
(OA-18) The Value of Progression-Free Survival (PFS) from the Perspectives of Patients with Multiple Myeloma (MM) and Treating Physicians: Quantitative Research Findings from Eight Countries
Imaging, QoL and Patient-Reported Outcome and Supportive Care
16:50 - 17:00 East Coast USA Time
(OA-19) Prospective Evaluation of Response Assessment in Newly-Diagnosed Multiple Myeloma with Combined use of 18F-FDG-PET/CT, Whole-Body Diffusion-Weighted MRI and MRD by Next-Generation Sequencing
Location: Room 701
Abstract Presenter: Marco Talarico, marco.talarico – Università di Bologna - IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli"
Imaging, QoL and Patient-Reported Outcome and Supportive Care
17:00 - 17:10 East Coast USA Time
(OA-21) Dynamic Frailty Analysis of Transplant-Ineligible (TIE) Patients with NDMM in the Phase 3 MAIA and CEPHEUS Trials of Daratumumab (Dara) + Lenalidomide-Dexamethasone (Rd) and Bortezomib-Rd (VRd)