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    Nursing and Allied Health Symposium

    Category: Nursing & Allied Health Symposium

    Myeloma Patient Outcome Scale (MyPOS): cross-cultural adaptation and evidence of validity for Brazilian population

    (NSP-20) Myeloma Patient Outcome Scale (MyPOS): Cross-cultural Adaptation and Evidence of Validity for Brazilian Population

    Thursday, September 18, 2025
    Introduction: The Myeloma Patient Outcome Scale (MyPOS) instrument was developed to monitor symptoms and improve the quality of life of people with multiple myeloma. This study intend to adapt to Brazilian culture and investigate psychometric properties of MyPOS.

    Methods: Methodological, cross-sectional, multicenter study. Stage 1: cross-cultural adaptation, which consisted of translation, back-translation and content validation of Portuguese version using the Delphi technique. Stage 2: search for evidence of the instrument's psychometric validity and its application to a population sample. Data factorability was assessed using the Kaiser-Meyer-Olkin (KMO) and Bartlett tests. The factor structure of the MyPOS was assessed using Exploratory Factor Analysis (EFA), with factor extraction using the Robust Diagonally Weighted Least Squares (RDWLS) method, a Robust Promin rotation method, and factor retention using parallel analysis with random data permutation. Internal consistency was measured by composite reliability and the stability of the extracted factor was assessed by the H index. To investigate evidence of validity through relationships with external measures, the EQ-5D-3L instrument was used, and to assess the stability of the instrument, the test-retest was performed at an interval of 10 to 14 days.

    Results: Content validity was obtained through the agreement of the expert committee, and the recommended Content Validity Index (≥ 0.9) was achieved in both rounds of analysis. The instrument was administered to 145 participants, predominantly female (57.93%), of mixed race and black (54.48%), with a median age of 68 years and a median time since diagnosis of 29 months. In the psychometric analysis, EFA suggested the retention of two factors. Factor 1 (Symptoms and Functioning) and Factor 2 (Emotional Response) explained, respectively, 30.61% and 10.42% of data variance. The instrument presented a multidimensional character, good reliability (ω coefficient for the general questionnaire: 0.873), and replicability of the factorial structure (H-Latent > 0.80).

    Conclusions: This study obtained evidence of validity and consistency for the Brazilian version of MyPOS, allowing its use in clinical practice and in other clinical trials that address this topic.